Objectives and techniques of chemical research. Assignment to research problem to be completed during two semesters.

Electronics as applied to chemical instrumentation; design and construction of instruments used in chemical research, analysis, recording, and control; maintenance and practice in modification to meet special needs.

Prerequisite: Permission of Instructor
To introduce the student to techniques for fabrication, characterization, and modeling of materials with an emphasis on nano-structures. Methods (top down) for the creation and characterization of nano-structures, band structure, conductivity, optical properties, and quantum confinement, assembly, liquids, and phase transitions.

Prerequisite: C361
Chemical applications of group theory and the elucidation of structure and bonding in inorganic molecules and complexes by vibrational, nuclear magnetic resonance, Mossbauer and electronic absorption spectroscopy.

Prerequisite: Permission of Instructor
To introduce the students to nano-scale and molecular materials. The first part will provide an overview of methods for bottom-up synthesis and assembly of nano-structures. The second part providing case studies from the recent literature; including: nano-particles, biological applications, molecular electronics, and machines, self-assembly in artificial and biological systems.

Prerequisite: Graduate standing
Elucidation of molecular structure utilizing IR, UV, and NMR spectroscopy, mass spectrometry, and other methods.

Prerequisite: Permission of Instructor
A one-semester overview of bottom-up fabrication of functional materials. Emphasis on the chemistry of molecularly defined assemblies constructed via non-covalent interactions. Topics include: synthetic strategies and physical properties, recognition, catalysis, sensing, switching, transport, and actuation, electron transfer and energy transfer, interfacial assemblies, mesoporous materials, polymers, dendrimers and liquid crystals.

Theory and practice of analytical separation techniques and analytical spectroscopy; chromatographic methods of separation, fundamentals of gas and liquid chromatography, overview of spectroscopic instrumentation, atomic and molecular spectroscopy for analysis.

Prerequisite: C362 & C342
Valence and molecule structure, electronic interpretation of organic reactions, stereochemistry.

Synthesis of organic compounds, degradation reactions, selected topics in organic reactions.

Prerequisite: Graduate standing or consent of instructor
Elements of quantum theory, solution of elementary problems with chemical applications, approximate methods, atomic structure, molecular symmetry and normal vibrations, the molecular orbital description of molecules.

Prerequisite: C561 or consent of instructor
Elements of quantum theory, solution of elementary problems with chemical applications, approximate methods, atomic structure, molecular symmetry and normal vibrations, the molecular orbital description of molecules.

Prerequisite: C561 or consent of instructor
Interaction of radiation with matter. Spectroscopic probes of the rotational, vibrational, and electronic structure of molecules. Advanced laser methods.

Prerequisite: Graduate standing or consent of instructor
Introduction to equilibrium and no equilibrium many-body systems using ensemble techniques. Emphasis on molecular systems and systems undergoing chemical transformation or transport. Both qualitative and rigorous approaches.

Prerequisite: C567 or consent of instructor
Selected topics such as pair correlation functions in classical liquids, laser and reaction-transport, nonequilibrium phenomena, critical phenomena, reaction rates, condensed media, NMR, precipitation and polymer kinetics, Green’s function methods, and computational methods.

Prerequisite: B501 or C483 or C484 or equivalent
Principals of inter-and intra-molecular interactions; structural stability of proteins and nucleic acids, thermodynamic and kinetic analysis of complex binding; experimental methods for analysis of macromolecular structure and binding. Credit given for only C581 or B503.

Theory and analysis of biochemical catalysis; enzyme kinetics; cofactors; regulation of enzymatic reactions.

Prerequisite: Concurrent or previous enrollment in B501/C584.
Critical evaluation of the biochemical literature using selected papers as examples; development of written and oral communication skills in the context of literature analysis. Meets with Bioc-B502. Credit given for only C583 or B502

Prerequisite: Undergraduate biochemistry (equivalent to C483 or C484 or consent of instructor.
Basic principles and methodologies of biochemistry. Essentials of macromolecular biosynthesis; mechanism-based examination of biochemical aspects of cell biology; material is presented with an integrative approach design to illustrate the interrelationship of biochemical processes. Meets with Bioc-B501. Credit given only for C584 or B501.

Theory and practice of electrochemical techniques (such as cyclic voltammetry, chronocoulometry, stripping analysis, thin-layer electrochemistry, and spectroelectrochemistry) used for analysis and for the characterization of inorganic and organic systems.

New instrumentation and techniques employed in spectrochemistry; indepth treatment of commonly used spectrochemical methods.

Topics in mass spectroscopic instrumentation and applications and in the natural chemistry of the stable isotopes of Carbon, Hydrogen, Nitrogen, Oxygen, Sulfur, and rare gases.

Theoretical and practical aspects of chromatographic methods of separation; fundamentals of gas and liquid chromatography, related instrumentation, and selected applications.

Introduction to surface analysis methods used to characterize chemical properties and phenomena at surfaces: structure, composition, adsorption, kinetics, reactions, catalysis, and growth. Photoelectron and x-ray absorption spectroscopies, thermal desorption, ion scattering, and scanning probe methods (AFM, STM, etc.). Emphasis will be on research problems in the current literature. Meets with Chemistry C668. Credit only given for C668 or C616.

Prerequisite: Consent of instructor.
Individual student seminars covering new methods or applications of chemical analysis or characterization. Required of all analytical chemistry majors.

Prerequisite: C502 and C561
Applications of quantum mechanics to the electronic and geometric structure of inorganic molecules. Advanced ligand field and molecular orbital theories. The Jahn-Teller effects and orbital symmetry studies of stereochemistry. Inorganic photochemistry.

General understanding and hands-on laboratory experience in crystallography as analytical method. Topics will onsist of theory on physics and mathematical concepts used in crystallography, the relation of physical and chemical properties to structure data, common databases, utilization of appropriate software for data work-up, solution, refinement, and visualization structures.

Introduction to the filed of bioinorganic chemistry and spectroscopic methods for determining structure/function relationship of metal ions in biology. Emphasis on oxygen carriers, metal ion transport and storage, as well as oxidoreductases involved in oxygen, hydrogen, and nitrogen metabolism.

The syntheses, structure, and industrial application of compounds and materials in which main group elements play a major role. All elements except the d-block transition metals are included as main group elements. This includes the f-block lanthanides and actinides as well.

Survey of the properties of the transition metals with emphasis on common oxidation levels, coordination geometries, and compounds with classical ligands: hard and soft acids and bases, dorbitals and their energies in different geometries; formation constants and the chelate effect; the Jahn-Teller theorem; low-intermediate, and high-spin systems; mixed valency; metal-ligand multiple bonding, metal-metal bonds; coordination clusters and their biological relevance.

Synthesis and reactivity of organo-main group and transition metal compounds, including application to organic synthesis.

Application of X-ray diffraction, dynamic NMR and mass spectroscopy to structural and mechanistic problems throughout the periodic table, with emphasis on what techniques are optimal for particular questions, as well as the potential weaknesses of each.

Prerequisite: Consent of instructor.
Topics not ordinarily covered by regularly scheduled courses, such as baron hydrides, X-ray diffraction, metal-metal bonds, bioinorganic chemistry, platinum metals chemistry, inorganic photochemistry, etc.

Definitions of diamagnetism, paramagnetism, magnetization and magnetic susceptibility; the Curie Law; orbital angular momentum; the Van Vleck equation; zero-field splitting; exchange interactions in dinuclear and polynuclear metal cluster, Basic concepts of paramagnetic NMR; spin delocalization mechanisms and isotropic shifts; contact and dipolar contributions. EPR of transition complexes; g-value anisotropy as a function of coordination geometry.

Prerequisite: C540 & C543 OR consent of instructor.
Synthesis and chemical-physical analysis of the structure of alkaloids, antibiotics, bacterial metabolites, plant pigments, steroids, and terpenes.

Prerequisite: C342 & C362
Application of physical-chemistry techniques to the study of structure and mechanism of reaction of organic compounds.

Prerequisite: Consent of instructor.
Recent developments in such areas as sulfur compounds, heterocycles, stereochemistry, polymers, and synthesis.

Prerequisite: Consent of instructor.
Topics such as materials chemistry or chemical applications of matrix algebra and group theory, digital computing techniques, solid state chemistry, high temperature processes, electrochemistry, theory of solutions, spectroscopy, and surface chemistry. (May be repeated with different topic.)

Mechanistic analysis of nucleic acid metabolism, specificity and role of DNA polymerases and repair pathways; DNA replication and recombination mechanisms; RNA structural motifs and physical processing in gene expression; catalytic RNA molecules; applications of RNA molecules.

Prerequisite: Consent of instructor.
Topics vary yearly and include the following: physio-chemical techniques in the study of macromolecules; experimental methods in enzymology; organic chemistry of enzymatic reactions and enzyme models; conformational properties and macromolecules. Meets with Bioc-B 680. Credit given for only C687 or B680 with same topic.

Prerequisite: Consent of instructor.
Recent advances in such areas as biological oxidations, energetics and equilibria, hormones, and nutrition. Meets with Bioc-B 600. Credit given for only C688 or B600.

Evaluation of second year analytical chemistry students.

The preparation and presentation of student research lectures based on current journals and other research literature in biological chemistry and related areas not closed related to the student’s own research.

Preparation and presentation of second year inorganic chemistry research project.

Preparation and presentation of student research lectures based on current journals and other research literature in materials chemistry and related areas on topics not closely related to the student’s own research.

Major topics in the filed of organic chemistry will be examined. A list of subjects will be provided at the beginning of the year.

Preparation and presentation of student research lectures based on current journals and other research literature in physical chemistry and related areas on topics not closely related to the student’s own research.

Continued research in the field of analytical chemistry.

Continued research in the field of materials chemistry.

Continued research in the field of inorganic chemistry.

Continued research in the field of organic chemistry.

Continued research in the field of physical chemistry.

Continued research in the field of biological chemistry.

Advanced research relating to the student's chosen research topic.