Our JEOL JEM 3200FS transmission electron microscope (TEM) is an intermediate voltage (300 kV) electron microscope similar to the one shown in this image from the JEOL USA website. This electron microscope uses a field emission gun (FEG) as its electron source, providing an extremely bright and coherent beam of electrons for use in imaging and analysis.

The 3200FS installed in Simon Hall during the last half of 2008 is equipped with an in-column energy filter and a Gatan UltraScan CCD camera. Note that the 3200FS is a different instrument from the JEOL JEM 3200FSC, which is the liquid helium cooled 300 kV TEM found in cryoEM facilities such the New York Structural Biology Center (NYSBC) and the National Center for Macromolecular Imaging (NCMI).

In addition to the TEM capabilities of the 3200FS, our instrument is also equipped with scan coils and detectors that allow it to function as a scanning transmission electron microscope (STEM). The dual capability of TEM and STEM makes them significantly different from dedicated STEM instruments like the Hitachi HD2700C or the VG HB501, and the designation (S)TEM is sometimes used to indicate an instrument is capable of both STEM and TEM imaging.

The mission of the METACyt Biochemical Analysis Center is to provide access and training for research in state of the art biochemical analysis. These activities promote best use of a wide variety of modern bioanalytical techniques including high resolution chromatography and multi-dimensional mass spectrometry. MBAC operates in widely diverse areas, such as proteomics, metabolomics and chemical structure elucidation.

Primary users of MBAC are: METACyt Nodes/Centers, their collaborators, faculty and students at IUB, the School of Medicine, and the IU system as a whole. Because of the unique nature of the center, and the wide applicability of biochemical analysis to many areas of scientific inquiry, special efforts are made at making the center accessible to as wide a range of scientists as possible.

The National Center for Glycomics and Glycoproteomics is devoted to the development of new methodologies and instrumentation in glycomics, proteomics, and glycoproteomics. In collaboration with researchers in biology and biomedical sciences at both national and international levels, the center promotes applications of new methodologies in medical research and clinical diagnosis. The NCGG houses a number of instruments that are used by staff scientists, post-doctorals, graduate students and undergraduates.

The aim of the NCGG is to utilize the analytical expertise at IU to advance breast cancer and neuroscience research; mobilize the nationally recognized strength of IU bioanalytical chemistry to advance measurement methodologies in functional glycomics, glycoproteomics, and proteomics; train and educate in these areas; provide dissemination of glycomic and proteomic expertise and analytical services throughout the geographical region; and to develop a liaison with other leading research centers under the recently formed Human Disease Glycomics/Proteome Initiative (HGPI) and Human Proteome Organization (HUPO).

The Center for Cell and Virus Theory is a research institute, with the main objective of developing mathematical and computational models of the physical and chemical processes for underlying cell and virus behavior. The CCVT addresses the challenge of understanding the workings of life on multi-, single- and sub-cellular scales. The interdisciplinary approach of the CCVT integrates methods from statistical mechanics, quantum chemistry, chemical kinetics, cell physiology, virology, biochemistry and computational sciences. Information theory is used to integrate models with data to produce a revolutionary automated model development, calibration and risk assessment approach.

Applications of our software include microarray, NMR and proteomic data analysis. Specific technologies also include drug and vaccine discovery, nanoparticle drug delivery, system design, environmental remediation and bio-reactor optimization. Disease groups under active research include those induced by viral and bacterial pathogens, cancer and diabetes.

The Linda and Jack Gill Center for Biomolecular Science (GCBS) was established to advance the understanding of complex biological processes and to train next generation scientists in state-of-the-art biomolecular measurements, especially in the field of neuroscience. Collaborations include Indiana University's world-class Departments of Biology, Chemistry, Physics, Psychological and Brain Science , Neuroscience, and the School of Medicine.

Specific GCBS Goals:

• Bring together multidisciplinary teams of world-class faculty interested in state-of-the-art biomolecular measurements to understand complex biological processes, especially neuroscience
• Provide training to graduate students from a range of disciplines in the use and development of measurement techniques and instrumentation
• Provide undergraduate students an opportunity to be involved in cutting-edge research projects
• Encourage interaction with industry in order to identify important problems and to commercialize advances
• Widely disseminate advances in complex biomolecular measurement techniques and instrumentation